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Progress on molecular biomarkers and classification of malignant gliomas
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《医学前沿(英文)》 2013年 第7卷 第2期 页码 150-156 doi: 10.1007/s11684-013-0267-1
Gliomas are the most common primary intracranial tumors in adults. Anaplastic gliomas (WHO grade III) and glioblastomas (WHO grade IV) represent the major groups of malignant gliomas in the brain. Several diagnostic, predictive, and prognostic biomarkers for malignant gliomas have been reported over the last few decades, and these markers have made great contributions to the accuracy of diagnosis, therapeutic decision making, and prognosis of patients. However, heterogeneity in patient outcomes may still be observed, which highlights the insufficiency of a classification system based purely on histopathology. Great efforts have been made to incorporate new information about the molecular landscape of gliomas into novel classifications that may potentially guide treatment. In this review, we summarize three distinctive biomarkers, three most commonly altered pathways, and three classifications based on microarray data in malignant gliomas.
关键词: malignant glioma molecular biomarker IDH1 MGMT molecular classification
Molecular classification and molecular targeted therapy of cancer
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《医学前沿(英文)》 2013年 第7卷 第2期 页码 147-149 doi: 10.1007/s11684-013-0274-2
Molecular classification and precision therapy of cancer: immune checkpoint inhibitors
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《医学前沿(英文)》 2018年 第12卷 第2期 页码 229-235 doi: 10.1007/s11684-017-0581-0
On May 23, 2017, the US Food and Drug Administration (FDA) approved a treatment for cancer patients with positive microsatellite instability-high (MSI-H) markers or mismatch repair deficient (dMMR) markers. This approach is the first approved tumor treatment using a common biomarker rather than specified tumor locations in the body. FDA previously approved Keytruda for treatment of several types of malignancies, such as metastatic melanoma, metastatic non-small-cell lung cancer, recurrent or metastatic head and neck cancer, refractory Hodgkin lymphoma, and urothelial carcinoma, all of which carry positive programmed death-1/programmed death-ligand 1 biomarkers. Therefore, indications of Keytruda significantly expanded. Several types of malignancies are disclosed by MSI-H status due to dMMR and characterized by increased neoantigen load, which elicits intense host immune response in tumor microenvironment, including portions of colorectal and gastric carcinomas. Currently, biomarker-based patient selection remains a challenge. Pathologists play important roles in evaluating histology and biomarker results and establishing detection methods. Taking gastric cancer as an example, its molecular classification is built on genome abnormalities, but it lacks acceptable clinical characteristics. Pathologists are expected to act as “genetic interpreters” or “genetic translators” and build a link between molecular subtypes with tumor histological features. Subsequently, by using their findings, oncologists will carry out targeted therapy based on molecular classification.
关键词: molecular classification precision medicine pembrolizumab PD-1/PD-L1 MSI-H
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《医学前沿(英文)》 2013年 第7卷 第2期 页码 157-171 doi: 10.1007/s11684-013-0272-4
Non-small-cell lung cancer (NSCLC) is the most common cause of premature death among the malignant diseases worldwide. The current staging criteria do not fully capture the complexity of this disease. Molecular biology techniques, particularly gene expression microarrays, proteomics, and next-generation sequencing, have recently been developed to facilitate effectively its molecular classification. The underlying etiology, pathogenesis, therapeutics, and prognosis of NSCLC based on an improved molecular classification scheme may promote individualized treatment and improve clinical outcomes. This review focuses on the molecular classification of NSCLC based on gene expression microarray technology reported during the past decade, as well as their applications for improving the diagnosis, staging and treatment of NSCLC, including the discovery of prognostic markers or potential therapeutic targets. We highlight some of the recent studies that may refine the identification of NSCLC subtypes using novel techniques such as epigenetics, proteomics, or deep sequencing.
关键词: non-small-cell lung cancer molecular typing individualized medicine molecular-targeted therapy gene expression profiling
Temporal and spatial stability of the EM/PM molecular subtypes in adult diffuse glioma
《医学前沿(英文)》 2023年 第17卷 第2期 页码 240-262 doi: 10.1007/s11684-022-0936-z
关键词: glioma progression molecular classification EM/PM subtyping intratumor heterogeneity
Molecular alterations and clinical relevance in esophageal squamous cell carcinoma
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《医学前沿(英文)》 2013年 第7卷 第4期 页码 401-410 doi: 10.1007/s11684-013-0286-y
Esophageal squamous cell carcinoma (ESCC) is one of the most common types of gastrointestinal cancers, and the fourth leading cause of cancer-related deaths in China. Early detection and intervention in time may dramatically increase the survival of the patients by initiating treatment regimens during earlier stages of ESCC or even during precancerous stages. Molecular classification will be useful for subtyping esophageal tumors or precancerous lesions to improve current therapeutics or early intervention of the disease. In this review, we summarize the findings in investigating the molecular alterations and clinical relevance of ESCC.
关键词: esophageal squamous cell carcinoma (ESCC) early detection molecular classification molecular markers
Translational medicine in hepatocellular carcinoma
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《医学前沿(英文)》 2012年 第6卷 第2期 页码 122-133 doi: 10.1007/s11684-012-0193-7
Hepatocellular carcinoma (HCC) is a highly complex disease that is generally resistant to commonly used chemotherapy and radiotherapy. Consequently, there is an urgent need for the development of new treatment strategies for this devastating disease. In the past decade, tremendous progress has been achieved in the molecular stratification of HCCs for diagnosis, prognosis, and therapeutic decision-making. To date, the molecular classification of HCCs has been carried out through transcriptomic, genetic and epigenetic profiling of tumors. Such research has led to identification of several potential molecular targets in HCC, and subsequently, development of novel systemic agents for the treatment of HCC has begun in earnest. In this article, we review the current knowledge of the molecular pathogenesis of HCC and outline potential areas for application of this knowledge in a clinical setting. As a typical virus and inflammation-associated cancer, both host immune response and tumor microenvironment have crucial roles in HCC pathogenesis. In addition, we examine the potential of immunotherapy and strategies targeting various components of the tumor microenvironment, as well as novel molecular and cellular targets in HCC such as cancer stem cells.
关键词: hepatocellular carcinoma molecular classification molecular targeted therapies tumor microenvironment immunotherapy
Asghar RAHMATI,Lohrasb FARAMARZI,Manouchehr SANEI
《结构与土木工程前沿(英文)》 2014年 第8卷 第4期 页码 448-455 doi: 10.1007/s11709-014-0262-x
An approach for mechanical fault classification based on generalized discriminant analysis
LI Wei-hua, SHI Tie-lin, YANG Shu-zi
《机械工程前沿(英文)》 2006年 第1卷 第3期 页码 292-298 doi: 10.1007/s11465-006-0022-2
关键词: generalized discriminant non-separable abnormality classification multi-faults classification
EAI-oriented information classification code system in manufacturing enterprises
WANG Junbiao, DENG Hu, JIANG Jianjun, YANG Binghong, WANG Bailing
《机械工程前沿(英文)》 2008年 第3卷 第1期 页码 81-85 doi: 10.1007/s11465-008-0011-8
K. Sathish KUMAR, T. JAYABARATHI
《能源前沿(英文)》 2012年 第6卷 第4期 页码 394-402 doi: 10.1007/s11708-012-0211-0
关键词: support vector machines (SVM) structural risk minimization (SRM) equivalent capacity margin (ECM) restoration fault classification
Special issue on “Molecular Sensors and Molecular Logic Gates”
Luling Wu , Tony D. James
《化学科学与工程前沿(英文)》 2022年 第16卷 第1期 页码 1-3 doi: 10.1007/s11705-021-2134-y
《化学科学与工程前沿(英文)》 2022年 第16卷 第2期 页码 168-182 doi: 10.1007/s11705-021-2056-8
关键词: computer-aided molecular design bio-oil additives molecular signature descriptor
Multiclass classification based on a deep convolutional
Ying CAI,Meng-long YANG,Jun LI
《信息与电子工程前沿(英文)》 2015年 第16卷 第11期 页码 930-939 doi: 10.1631/FITEE.1500125
关键词: Head pose estimation Deep convolutional neural network Multiclass classification
Xinjun LIU, Xiang CHEN, Zhidong LI
《机械工程前沿(英文)》 2012年 第7卷 第2期 页码 199-209 doi: 10.1007/s11465-012-0315-6
Due to the demand of reconfigurable system in parallel kinematic machines (PKMs), modular design technology is significant and necessary. However, in earlier research, the core joint modules have been concerned about rather than the customized link modules. The modular design to the typical customized links from the point of seeking optimal structures with best mechanical performances is analyzed and processed in two steps: classification and optimization. Firstly, a brief introduction to the current research status and the aims of this paper are outlined. And then, how the typical customized links classified is proposed. Next, the technology method and the iterative formula derivation process of topology optimization are described in detail. Finally, calculation models for each group of classified ones are set up and their optimal structures are achieved through topology optimization technique. The results provide useful references for reconfigurable and modular design in engineering cases.
关键词: parallel kinematic machines (PKMs) modular design classification topology optimization and improved Guide-Weight method
标题 作者 时间 类型 操作
Molecular classification of non-small-cell lung cancer: diagnosis, individualized treatment, and prognosis
null
期刊论文
Development of a new method for RMR and Q classification method to optimize support system in tunneling
Asghar RAHMATI,Lohrasb FARAMARZI,Manouchehr SANEI
期刊论文
An approach for mechanical fault classification based on generalized discriminant analysis
LI Wei-hua, SHI Tie-lin, YANG Shu-zi
期刊论文
EAI-oriented information classification code system in manufacturing enterprises
WANG Junbiao, DENG Hu, JIANG Jianjun, YANG Binghong, WANG Bailing
期刊论文
Fault classification and reconfiguration of distribution systems using equivalent capacity margin method
K. Sathish KUMAR, T. JAYABARATHI
期刊论文
Design of bio-oil additives via molecular signature descriptors using a multi-stage computer-aided molecular
期刊论文